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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B3
All Species:
29.7
Human Site:
Y417
Identified Species:
59.39
UniProt:
Q02153
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02153
NP_000848.1
619
70514
Y417
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
Y417
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Rat
Rattus norvegicus
P20595
619
70438
Y417
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510819
683
77917
Y440
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Chicken
Gallus gallus
XP_420376
698
78758
Y499
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Frog
Xenopus laevis
NP_001085192
609
69543
A414
R
H
K
R
P
V
P
A
K
R
Y
D
N
V
T
Zebra Danio
Brachydanio rerio
XP_001920263
608
69179
P411
N
E
L
R
H
K
R
P
V
P
A
K
R
Y
D
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
Y417
R
P
V
P
A
K
R
Y
D
N
V
T
I
L
F
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
F417
P
I
D
T
C
E
M
F
D
S
V
S
I
L
F
Honey Bee
Apis mellifera
NP_001011632
603
68286
Y407
R
P
V
P
A
K
K
Y
D
C
V
T
L
L
F
Nematode Worm
Caenorhab. elegans
Q6DNF4
675
76632
Y446
L
S
V
E
A
R
E
Y
E
E
A
T
V
M
F
Sea Urchin
Strong. purpuratus
P16065
1125
126238
F910
I
A
V
L
P
E
T
F
E
M
V
S
I
F
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
98.7
98.8
N.A.
88.2
85.8
93.6
88
87.4
24.2
63.8
32.2
20.1
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
99.3
99.5
N.A.
89.5
86.9
96.2
93.6
94
38.6
77.7
52.4
32.5
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
6.6
13.3
100
33.3
80
33.3
26.6
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
13.3
20
100
60
93.3
60
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
67
0
0
9
0
0
17
0
0
0
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
0
67
0
0
9
0
0
9
% D
% Glu:
0
9
0
9
0
17
9
0
17
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
17
0
0
0
0
0
9
84
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
0
0
0
0
0
0
0
0
0
0
67
0
0
% I
% Lys:
0
0
9
0
0
67
9
0
9
0
0
9
0
0
0
% K
% Leu:
9
0
9
9
0
0
0
0
0
0
0
0
9
67
0
% L
% Met:
0
0
0
0
0
0
9
0
0
9
0
0
0
9
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
50
0
0
9
0
0
% N
% Pro:
9
59
0
59
17
0
9
9
0
9
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
67
0
0
17
0
9
59
0
0
9
0
0
9
0
0
% R
% Ser:
0
9
0
0
0
0
0
0
0
9
0
17
0
0
0
% S
% Thr:
0
0
0
9
0
0
9
0
0
0
0
67
0
0
9
% T
% Val:
0
0
75
0
0
9
0
0
9
0
75
0
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
67
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _